Protein function prediction: towards integration of similarity metrics

Serkan Erdin, Andreas Martin Lisewski, Olivier Lichtarge
2011 Current Opinion in Structural Biology  
Genomic centers discover increasingly many protein sequences and structures, but not necessarily their full biological functions. Thus, currently, less than one percent of proteins have experimentally verified biochemical activities. To fill this gap, function prediction algorithms apply metrics of similarity between proteins on the premise that those sufficiently alike in sequence, or structure, will perform identical functions. Although high sensitivity is elusive, network analyses that
more » ... ate these metrics together hold the promise of rapid gains in function prediction specificity.
doi:10.1016/j.sbi.2011.02.001 pmid:21353529 pmcid:PMC3120633 fatcat:2y5fgugnyza25b3qm2jnd76lwa