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Circulating RNAs, especially microRNAs (miRNAs) have recently emerged as non-invasive disease biomarkers. Despite enthusiasm and numerous reports on disease associated circulating miRNAs, currently there is no circulating miRNA-based diagnostic in use. In addition, there are many contradictory reports on the concentration changes of specific miRNA in circulation. Here we review the impact of various technical and non-technical factors related to circulating miRNA measurement and elucidate thedoi:10.1007/s40291-016-0251-y pmid:28039578 pmcid:PMC5426982 fatcat:56s42d6l6narze4mp6lhnxubda