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Decision letter: Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding
[peer_review]
2019
unpublished
Mammalian mitochondrial inner membrane fusion is mediated by optic atrophy 1 (OPA1). Under physiological conditions, OPA1 undergoes proteolytic processing to form a membrane-anchored long isoform (L-OPA1) and a soluble short isoform (S-OPA1). A combination of L-OPA1 and S-OPA1 is essential for efficient membrane fusion; however, the relevant mechanism is not well understood. In this study, we investigate the cryo-electron microscopic structures of S-OPA1-coated liposomes in nucleotide-free and
doi:10.7554/elife.50294.sa1
fatcat:ofxl3onzyzgnhigbfsq6qmroxi