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Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders
Puberty is a critical period of development marked by the maturation of the central nervous system, immune system, and hypothalamic–pituitary–adrenal axis. Due to the maturation of these fundamental systems, this is a period of development that is particularly sensitive to stressors, increasing susceptibility to neurodevelopmental and neurodegenerative disorders later in life. The gut microbiome plays a critical role in the regulation of stress and immune responses, and gut dysbiosis has beendoi:10.3390/microorganisms10112163 pmid:36363755 pmcid:PMC9697368 fatcat:xw4bk4xsuzdxbhaa5mr6xx4dcq