In October 1890, Dr Bramwell sent to the Laboratory a small quantity of urine, with a request that I should give him a report upon it. To him I am indebted for the opportunity of making the series of observations here recorded.On examination, I found that the amount of proteid was enormous, and that it was made up almost entirely of a globulin :—This condition of the urine persisted, with only slight changes, until the death of the patient.