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In January 2020, the author found that novel coronaviruses are prone to mutation, and strong pathogenic mutations may occur from time to time due to the morphological and structural characteristics of SARS-COV-2. It is difficult or impossible for COVID-19 vaccines to prevent future COVID-19 infections, and unexpected adverse reactions may occur. Mass vaccination without regard to timing does not conform to the principles of medical behavioral economics and puts a heavy burden on the government.doi:10.5281/zenodo.7516443 fatcat:igxjcl3f7ne2rjsdlfdjjb6n3q