The study of antiepileptic activity of clove oil by MES model in mice

E Avanthi, L Pradeep Kumar, BN Lokesh, Yadavalli Guruprasad
2016 Indian Journal of Pharmacy and Pharmacology  
The objective was to evaluate and compare the effect of extract of essential oil of clove with the standard sodium valproate on MES model. Methods: A total of thirty mice were taken, they were given an electroconvulsive shock. Thirty mice were divided into five groups of six animals each, the control group received distilled water 5ml/kg i.p, standard received Inj. Sodium valproate 200 mg/kg i.p. another group received Sesame oil -10ml/kg i.p(control), test groups received Clove oil-0.075 ml/kg
more » ... ove oil-0.075 ml/kg i.p., Clove oil-0.1ml/kg i.p respectively. All the injections were given 30 minutes before the test. Results: Clove oil produced significant antiepileptic effect at all the doses. Conclusion: Clove oil has shown significant antiepileptic activity in mice.
doi:10.5958/2393-9087.2016.00024.8 fatcat:n2pe75iwhvbfxjfpedpen4r47q