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Key Words life span, oxidative stress, insulin/IGF-like signaling, caloric restriction, gene expression s Abstract Research into the mechanisms underlying the process of aging is emerging as an exciting area of biomedical research. Observations challenging the fundamental assumptions of aging have begun to rejuvenate the field, opening up aging research to fresh ideas and approaches. Genetic approaches, which have been successfully used to understand other complex biological phenomena, aredoi:10.1146/annurev.genet.37.040103.095211 pmid:14616064 fatcat:m5jtcdhbjzhavnci52rgdqazcu