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Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death
Molecular Cancer Therapeutics
In breast cancer, radiation has a central role in the treatment of brain metastasis, although tumor sensitivity might be limited. The tumor cell defense response to ionizing radiation involves activation of cell cycle checkpoint signaling. Histone deacetylase (HDAC) inhibitors, agents that cause hyperacetylation of histone proteins and thereby aberrations in the chromatin structure, may also override the DNA damage defense response and facilitate the radiation-induced mitotic cell death. Indoi:10.1158/1535-7163.mct-04-0304 pmid:16093439 fatcat:nfmtddmgz5bxzhu6c2pdusnhbq