Antioxidant and acetylcholinesterase inhibitory activity of the three species namely, Endostemon obtusifolius (E. Mey. ex benth.) N. E. Br, Plectranthus zuluensis (T. Cooke) and Tetradenia riparia (Hochst.) Codd. were evaluated. Maximum antioxidant activity was exhibited by E. obtusifolius (IC 50 130 µg/ml) followed by T. riparia (IC 50 142 µg/ml) and P. zuluensis (IC 50 169 µg/ml). Acetylcholinesterase inhibition (AChEI) was highest in P. zuluensis (IC 50 290 µg/ml) followed by E. obtusifolius

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... (IC 50 470 µg/ml) and T. riparia (IC 50 750µg/ml). The results suggest that these three species possess natural antioxidants and acetylcholinesterase inhibitors, which may be beneficial for the treatment of Alzheimer's disease, that require high concentration of these compounds.