BLOOD CHEMISTRY OF PERNICIOUS ANEMIA

ALEXANDER O. GETTLER
1920 Archives of Internal Medicine  
recently published an admirable paper in which they report the results of the blood analyses and the functional capacity of the various organs in three cases of pernicious anemia. Their study revealed the following conditions : Stomach : Gastric stasis seemed to be present ; free acid and pepsin absent. The mucosa appeared to be nonfunctioning, the result of atrophy. Intestines : Digestion and absorption, especially that of the proteins, were disturbed and below normal. Intestinal putrefaction
more » ... tinal putrefaction was increased. Pancreas : The pancreatic enzymes were present in normal amounts and tests showed that the pancreas was functioning normally. Liver: The function of detoxication was deficient. Other functions, such as the glycogenic, ureogenic, biligenic, were normal. Pigments : Both pleochromic and urobilinocholia existed, showing that excessive hemolysis was going on. Kidneys : The excretory function of the kidneys was normal. Urine: Quantitative partition nitrogen determinations proved the normal output of the excretory nitrogenous substances with the exception of a greatly increased oxyproteic acid. Blood : The nonprotein nitrogen, urea and uric acid content was normal. The creatinin was increased. The glucose, fat, and choles¬ terol were normal. The alkaline reserve was below normal, showing an acidosis. The specific gravity of the plasma was lowered and the protein content was much reduced. The ash and calcium were slightly increased. The work reported in the present paper deals solely with the analysis of the blood. The work was started in 1916. Thirty-two cases have been studied. In most of the cases several complete blood analyses were made at intervals of a month or more.
doi:10.1001/archinte.1920.00100040076008 fatcat:4bx7qniwlng6ddi3dtxbgmx22m