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Crystalline Drug Aconitine-loaded Poly(d,l-Lactide-CoGlycolide) Nanoparticles: Preparation and in Vitro Release
This paper reports both the optimization of aconitine entrapment and its release from biodegradable poly(d,l-lactide-coglycolide) (PLGA) nanoparticles prepared using the O/W single-emulsion/solvent-evaporation technique. The in‰uence of several parameters, such as the initial aconitine mass, aqueous-phase pH, volume ratio of aqueous/organic phase (W/O), PLGA concentration in the organic phase, etc., on aconitine encapsulation were investigated. The optimized nanoparticles had an entrapmentdoi:10.1248/yakushi.130.409 pmid:20190525 fatcat:6wcpt2layfalbpk6wcvzfrbdim