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Tumors developing in oophorectomized Sprague-Dawley rats after a single gastric instillation of 7,12-dimethylbenz(a)anthracene
The present report describes the various types of tumors which developed in female Sprague-Dawley rats oophoreetomized at age 46 days and fed a single dose of 20 mg 7,12-dimethylbenz(a)anthracene one week later. This method, which is known to induce breast carcinoma invariably in normal female rats of this strain, produced mammary cancer in only 5% of the oophorectomized rats, after a period of observation of about a year. In contrast, a high percentage of rats presented tumors of the ear ductpmid:5641521 fatcat:42vgxvdwb5g3rm46hvh2okk7ci