Avaliação da saúde bucal e padrão da excreção salivar dos herpesvírus em indivíduos transplantados renais [thesis]

Dmitry José de Santana Sarmento
Sarmento DJS. Evaluation of oral health and salivary shedding of herpesviruses in renal transplant recipients [thesis]. São Paulo: Universidade de São Paulo, Faculdade de Odontologia; 2019. Versão Corrigida. Kidney transplantation is the most effective therapy for end-stage renal disease, but its longevity depends on several approaches, including the chronic use of immunosuppressive drugs, which predispose opportunistic infections, such as herpesvirus, being one of the main causes of morbidity
more » ... auses of morbidity and mortality to transplant recipients. The literature presents several articles focusing on the type and frequency of oral manifestations in long-term of transplant renal, but is scarce in research that provides scientific evidence in short-term of transplant, especially regarding oral health and its impact on transplantation renal. Another area of scientific interest and little addressed is the use of saliva to detect and monitor herpesviridae virus infection. This thesis presents a compilation of three chapters that addressed oral health, oral manifestations, and salivary shedding of herpesvirus in kidney transplant recipients. The studies aimed to: evaluate the impact of patients' pre-transplant oral health on the short-term outcome of kidney transplantation and to determine the incidence of hospitalization for odontogenic causes; identify oral lesions of individuals with kidney disease immediately before and soon after kidney transplantation; and to evaluate salivary excretion and viremia of herpesvirus in recipients renal transplant. Cohort studies were developed where a single trained dentist collected data for three consecutive periods: within 24 hours prior to transplantation; 15 to 20 days after transplantation; and 45 to 60 days after transplantation. Patients were evaluated for oral health, clinical presence of oral lesions / alterations. Saliva and blood were collected for herpesvirus detection, all samples were subjected to polymerase chain detection (Panherpes) and subsequent enzymatic digestion for the detection of eight human herpesviruses. In the first study, it was observed that transplanted patients with advanced age (p = 0.004; OR: 1.10; 95% CI 1.03-1.17) had a higher risk of hospitalization with each year of life; and patients with odontogenic infection in pretransplant (p = 0.009; OR: 8.36; 95% CI 1.68-41.46) were 8.36 more likely to be
doi:10.11606/t.23.2019.tde-30072020-100434 fatcat:juyjzloc7bbrpos7ysmerbmkwu