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Profound alteration in cutaneous primary afferent activity produced by inflammatory mediators
2016
eLife
Inflammatory pain is thought to arise from increased transmission from nociceptors and recruitment of 'silent' afferents. To evaluate inflammation-induced changes, mice expressing GCaMP3 in cutaneous sensory neurons were generated and neuronal responses to mechanical stimulation in vivo before and after subcutaneous infusion of an 'inflammatory soup' (IS) were imaged in an unanesthetized preparation. Infusion of IS rapidly altered mechanical responsiveness in the majority of neurons.
doi:10.7554/elife.20527
pmid:27805567
pmcid:PMC5117853
fatcat:6i4arh354rewvo4mmma3vtsg5a