Serum sialic acid and its lipid and protein bounds as possible biomarkers of acute myocardial infarction in Erbil city

Rasul Aziz, Tayfoor Mahmoud, Hamid Hassan
2011 Zanco Journal of Medical Sciences  
Backgrounds and objectives: Myocardial infarction (MI) usually occurs when coronary blood flow decreases abruptly after a thrombotic occlusion of a coronary artery previously affected by atherosclerosis. Sialic acid (SA) is attached to non reducing residues of the carbohydrate chains of glycoproteins and glycolipids. An elevation in serum TSA , LBSA and PBSA concentrations has been observed in a number of pathological conditions .The aim of the study was to determine the serum TSA and its LBSA
more » ... nd PBSA in patients with acute myocardial infarction (AMI). Methods: Serum TSA , LBSA and PBSA concentrations were evaluated by UV/VIS spectrophotometry in (100) apparently healthy individuals and ( 100 ) newly diagnosed AMI patients . Results: The mean levels of serum TSA , LBSA and PBSA in AMI patients were significantly higher ( P < 0.05 ) than those of apparently healthy individuals . Conclusion: The results indicate that the serum values of TSA, LBSA and PBSA appeared to be of a value in diagnosis of AMI . Acute myocardial infarction (AMI) is one of the major causes of mortality and morbidity in the world. The most common cause of AMI is atherosclerotic ischemic heart disease (IHD) with fissuring or ulceration of a plaque causing clotting and complete arterial occlusion 1 . Several risk factors for AMI have been well documented, including hypertension, hyperlipidaemia, diabetes, a positive family history, smoking, obesity and inactivity. However, these factors explain only part of attributable AMI 2 . Sialic acid (SA) an important component of glycolipids and glycoproteins , is found in negatively charged surface polyanions on various cell membranes and play an important role in the antigenic characterization of cells 3 .
doi:10.15218/zjms.2011.0010 fatcat:owauwjwkyndilgeg6lsiiohwsa