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Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1B
Journal of Biological Chemistry
Growth factors induce intracellular production of reactive oxygen species in non-phagocytic cells and elevation of their phosphorylated protein tyrosine level. The latter can be achieved by activating protein-tyrosine kinases and/or inactivating protein-tyrosine phosphatases (PTPs). A highly abundant PTP, PTP-1B, is known to be inactivated by oxidation of its catalytic site Cys-215. We show that O 2 . is kinetically more efficient and chemically more specific oxidant than H 2 O 2 fordoi:10.1074/jbc.274.49.34543 pmid:10574916 fatcat:4icy4mp7yzfaxlgliagddwnbmu