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Derivation of a No-significant-risk-level (NSRL) for dermal exposures to diethanolamine
Regulatory toxicology and pharmacology
Diethanolamine (DEA) has been found to produce liver and kidney tumors in mice following lifetime dermal exposures. Data regarding the mode of action by which DEA produces these tumors were used to support a dose-response assessment that resulted in a no-significant-risk-level (NSRL) for dermal exposures to DEA. DEA and its metabolites are structural analogs to endogenous agents important to choline homeostasis. Sufficient information is available to support an epigenetic MOA involving thedoi:10.1016/j.yrtph.2016.01.020 pmid:26850685 fatcat:uztcml2qabc3fokgxvcohsjdgu