Eradication of neuroblastoma by T cells redirected with an optimized GD2-specific chimeric antigen receptor and interleukin-15

Yuhui Chen, Chuang Sun, Elisa Landoni, Leonid S Metelitsa, Gianpietro Dotti, Barbara Savoldo
2019 Clinical Cancer Research  
A delay in encountering the cognate antigen while in the circulation, and the suboptimal costimulation received at the tumor site are key reasons for the limited activity of chimeric antigen receptor-redirected T cells (CAR-T) in solid tumors. We have explored the benefits of incorporating the IL15 cytokine within the CAR cassette to provide both a survival signal before antigen encounter, and an additional cytokine signaling at the tumor site using a neuroblastoma tumor model.
doi:10.1158/1078-0432.ccr-18-1811 pmid:30617136 fatcat:vxbut4f75rbxxiai6kzlzkinsq