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Expression of the precore region of an avian hepatitis B virus is not required for viral replication
Journal of Virology
The core-antigen-coding region of all hepadnaviruses is preceded by a short, in-phase open reading frame termed precore whose expression can give rise to core-antigen-related polypeptides. To explore the functional significance of precore expression in ,yivo, we introduced a frameshift mutation into this region of the duck hepatitis B virus (DHBV) genome and examined the phenotype of this mutant DNA by intrahepatic inoculation into newborn ducklings. Animals receiving mutant DNA developed DHBVdoi:10.1128/jvi.61.10.3322-3325.1987 fatcat:kr2737hcxbbdlpg2thbdibx32m