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Long-term exposure to arsenic is associated with cancers of lung, urinary bladder, kidney, liver and skin. Arsenic carcinogenesis might result from oxidative stress, altered growth factors, chromosomal abnormality, immune dysregulation, and aberrant epigenetic regulations. Bowen's disease (As-BD) is the most common form of arsenic-induces skin cancers and is characterized by chronicity, multiplicity, and predisposition in sun-spare skin. However, only about 1% of the population exposed todoi:10.4236/jct.2010.12013 fatcat:4z3ql576hndktg4dd5f26gsdsa