Internal Pair Production of 90Y Permits Hepatic Localization of Microspheres Using Routine PET: Proof of Concept

V. L. Gates, A. A. H. Esmail, K. Marshall, S. Spies, R. Salem
2010 Journal of Nuclear Medicine  
Radioembolization with 90 Y microspheres represents a novel transarterial radiation treatment for liver tumors. The purpose of this pilot study was to evaluate the findings of postimplantation PET/CT of 90 Y glass microspheres. Methods: Three patients with hepatocellular carcinoma and 2 patients with liver metastases (1 neuroendocrine, 1 colorectal) underwent PET/CT after radioembolization. Four patients underwent imaging at 1 mo to assess response and confirm PET/CT findings; 1 patient
more » ... t PET/CT at 4 d after 90 Y implantation. Patients were followed for adverse events. Results: Standard PET/CT enabled the localization of 90 Y glass microspheres for all patients. None of the patients experienced adverse events related to nontarget deposition. Conclusion: Standard PET/CT may be used to assess the localization of 90 Y glass microspheres. This approach provides a simple, rapid, and universally applicable method of confirming microsphere deposition. With further validation, this technique may potentially become the standard of care for confirming microsphere distribution.
doi:10.2967/jnumed.110.080986 pmid:21149493 fatcat:gvurta5w6fanbj45axa2srmdhu