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Faculty of 1000 evaluation for Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis
F1000 - Post-publication peer review of the biomedical literature
Adult neurogenesis, a process of generating mature neurons from adult neural stem cells, proceeds concurrently with ongoing neuronal circuit activity and is modulated by various physiological and pathological stimuli. The niche mechanism underlying activity-dependent regulation of sequential steps of adult neurogenesis remains largely unknown. Here we report that neuronal activity decreases the expression of secreted frizzled-related protein 3 (sFRP3), a naturally secreted Wnt inhibitor highlydoi:10.3410/f.717977664.793475225 fatcat:zraum5iuznfglbvdvbxgnj42fa