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Although much of the emphasis in treating Bipolar Disorder patients is on pharmacotherapy, sleep loss is an important trigger for mania and plays an important role in the condition. The purpose of this paper is to fully explore the chronobiological, environmental, social, and genetic factors that contribute to the sleep disruption that is characteristic of mania and bipolar disorder. This review is important because sleep, chronobiology, and genetics are under-emphasized content areas indoi:10.1080/01612840591008267 pmid:16126647 fatcat:gvalndqjtbcl7of3yacl6i36ta