Human autoantibodies against desmoplakins in paraneoplastic pemphigus. J Clin Invest 89:1775-82 Rafei D, Muller R, Ishii N et al. (2011) IgG autoantibodies against desmocollin 3 in pemphigus sera induce loss of keratinocyte adhesion. Am J Pathol 178:718-23 Schepens I, Jaunin F, Begre N et al. (2010) The protease inhibitor alpha-2-macroglobulinlike-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human. PLoS ONE 5:e12250 Spindler V, Heupel WM, Efthymiadis A et al.

more »

... 009) Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus. Abbreviations: COL7A1D87, COL7A1 mRNA with deleted exon 87; COL7A1WT, wild-type COL7A1 mRNA; DDEB, dominant dystrophic epidermolysis bullosa; D87, in-frame skipping of COL7A1 exon 87; IRES, internal ribosome entry site; NC, negative control siRNA; RISC, RNA-induced silencing complex; siRNA, small interfering RNA; siwt, positive control siRNA; WT, wild type www.jidonline.org 1741 V Pendaries et al. siRNA-Mediated Allele-Specific Inhibition in DDEB Sakuntabhai A, Hammami-Hauasli N, Bodemer C et al. (1998) Deletions within COL7A1 exons distant from consensus splice sites alter splicing and produce shortened polypeptides in dominant dystrophic epidermolysis bullosa. Am J Hum Genet 63:737-48 Vert JP, Foveau N, Lajaunie C et al. (2006) An accurate and interpretable model for siRNA efficacy prediction. BMC Bioinformatics 7:520 www.jidonline.org 1743 V Pendaries et al. siRNA-Mediated Allele-Specific Inhibition in DDEB