This is a discussion of paper "Treelets--An adaptive multi-scale basis for sparse unordered data" [arXiv:0707.0481] by Ann B. Lee, Boaz Nadler and Larry Wasserman. In this paper the authors defined a new type of dimension reduction algorithm, namely, the treelet algorithm. The treelet method has the merit of being completely data driven, and its decomposition is easier to interpret as compared to PCR. It is suitable in some certain situations, but it also has its own limitations. I will discuss

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... both the strength and the weakness of this method when applied to microarray data analysis.