STUDIES ON IMIDOCARB DIHYDROCHLORIDE IN EXPERIMENTAL BABESIA BIGEMINA INFECTION IN CALVES (*)

R Rashemi-Fesharki
1976 Arch. IDst. Razi   unpublished
Four chemotherapeutic trials in Iran with the babesicide 3,3-bis-(2-imi-dazoline-2-yl) carbanilide dihydrochloride (Imidocarb dihydrochloride) are reported. Subcutaneous administration at a dose of l mg/kg proved highly effective in controlling experimental infection with a local virulent strain of Babesia bigemina in calves. While treated calves were apparently sterilized of the infection, they subsequently (100 days) were resistant to clinical re-infection despite the development-of a low
more » ... opment-of a low parasitaemia. No toxic effects attributable to the administration of the therapeutie-dose of l mg/kg Imidocarb dihydrochloride were observed. Only mild and transient side effects were observed at 5 mg/kg and at 10 mg/kg; one of four calves died 12 days after the injection. The compound was considered to have a satisfactory therapeutic index and was shown to be less toxic and mOre effective in the treatment of B. bigemina infection than the therapeutic N,N-(dimethyl-quinolylium-methylsulphate-6)-urea (Acaprin), currently available in Iran.
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