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C-H-Activation approach in the synthesis of palonosetron core: A 5-HT3 receptor antagonist
2021
The Pharma Innovation
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Intramolecular rhodium (III) catalyzed annulation of benzamide 8 has been described in the efficient synthesis of palonosetron core, 5-HT3 receptor antagonists. C-H-activation enabled the simultaneous generation of rings B and C, which can further be functionalized to access a series alkaloid.
doi:10.22271/tpi.2021.v10.i4a.7386
fatcat:tjsxjw7j4bchjpxbht6q53c5bi