C-H-Activation approach in the synthesis of palonosetron core: A 5-HT3 receptor antagonist

Vivek K Mishra, Martin E Maier
2021 The Pharma Innovation  
Intramolecular rhodium (III) catalyzed annulation of benzamide 8 has been described in the efficient synthesis of palonosetron core, 5-HT3 receptor antagonists. C-H-activation enabled the simultaneous generation of rings B and C, which can further be functionalized to access a series alkaloid.
doi:10.22271/tpi.2021.v10.i4a.7386 fatcat:tjsxjw7j4bchjpxbht6q53c5bi