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Synthesis of 1-Indolyl-3,5,8-Substituted γ-Carbolines: One Pot Metal-Solvent Free Protocol and Biological Evaluation
[post]
2020
unpublished
Preserved Fulltext
1,5-Disubstituted indole-2-carboxaldehyde derivatives (1a–h) and glycine alkyl esters (2a–c) are shown to undergo a novel cascade imination-heterocylisation in the presence of organic base DIPEA to provide 1-indolyl 3,5,8-substituted g-carbolines (3aa–ea) in good yields. The g-carbolines are fluorescent and exhibit anticancer activities against cervical, lung, breast, skin and kidney cancers.
doi:10.3762/bxiv.2020.131.v1
fatcat:j4ah7wsyjngpflikd7vu22ocsi