NEUTROPHIL-TUMOR CELL PHAGOCYTOSIS (CANNIBALISM) IN HUMAN TUMORS: AN UPDATE AND LITERATURE REVIEW

R Caruso, F Fedele, G Finocchiaro, G Arena, A Venuti
2012 Experimental Oncology   unpublished
The recognition and removal of apoptotic cells by tissue macrophages and nonprofessional phagocytes, in a process called effero-cytosis, is critical for development, tissue homeostasis and resolution of inflammation. Apoptotic bodies arising in tumor tissue are ingested by viable neoplastic cells and by resident macrophages. We described tumor cell phagocytosis of apoptotic neutrophils in human gastric carcinomas. This phenomenon is analogous to neutrophil efferocytosis performed by macrophages
more » ... and by non-professional phagocytes during inflammatory reaction but is distinct by other types of cell-in-cell phenomena including emperipole-sis and entosis both cytologically and biologically. In this review, we discussed them in their ultrastructural morphology, physiological roles, and clinicopathologic implications. This article is part of a Special Issue entitled "Apoptosis: Four Decades Later".
fatcat:wjuefmi2qzahjl4uorv7f2fp4i