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To understand the factors that alter sleep quality in space, we studied the effect of spaceflight on sleep-disordered breathing. We analyzed 77 8-h, full polysomnographic recordings (PSGs) from five healthy subjects before spaceflight, on four occasions per subject during either a 16-or 9-d space shuttle mission and shortly after return to earth. Microgravity was associated with a 55% reduction in the apnea-hypopnea index (AHI), which decreased from a preflight value of 8.3 Ϯ 1.6 to 3.4 Ϯ 0.8doi:10.1164/ajrccm.164.3.2010081 pmid:11500354 fatcat:ohc6p4c5ardadfej3z5kymieou