Human connectomics

Timothy EJ Behrens, Olaf Sporns
2012 Current Opinion in Neurobiology  
Recent advances in non-invasive neuroimaging have enabled the measurement of connections between distant regions in the living human brain, thus opening up a new field of research: Human connectomics. Different imaging modalities allow the mapping of structural connections (axonal fiber tracts) as well as functional connections (correlations in time series), and individual variations in these connections may be related to individual variations in behaviour and cognition. Connectivity analysis
more » ... s already led to several important advances. Segregated brain regions may be identified by their unique patterns of connectivity, structural and functional connectivity may be compared to elucidate how dynamic interactions arise from the anatomical substrate, and the architecture of large-scale networks connecting sets of brain regions may be analyzed in detail. The combination of structural and functional connectivity has begun to reveal key patterns of human brain organization, such as the existence of distinct modules or sub-networks that become engaged in different cognitive tasks. Collectively, advances in human connectomics open up the possibility of studying how brain connections mediate regional brain function and thence behaviour.
doi:10.1016/j.conb.2011.08.005 pmid:21908183 pmcid:PMC3294015 fatcat:3ivb6cw6vrhrjksrp2faxrq5lm