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A high-fat, refined-carbohydrate diet affects renal NO synthase protein expression and salt sensitivity
Journal of applied physiology
A high-fat, refined-carbohydrate diet affects renal NO synthase protein expression and salt sensitivity. a high-fat, refined-carbohydrate (HFS) diet causes hypertension. In an earlier study, we found increased nitric oxide (NO) inactivation by reactive oxygen species (ROS) and functional NO deficiency in this model. Given the critical role of NO in renal sodium handling, we hypothesized that diet-induced hypertension may be associated with salt sensitivity. Female Fischer rats were fed an HFSdoi:10.1152/japplphysiol.00536.2002 pmid:12433862 fatcat:srfeksszarfvdgmkohtw3na6xi