Abstract: Papaya (Carica papaya) is a tropical fruit having commercial importance because of its high nutritive and medicinal value. Papaya seeds are traditionally used by human beings from centuries to heal many illnesses. Papaya seeds contains antioxidants and antimicrobial virtues which gives protection against harmful free radicals and reduce rate of cancer and heart disease. Papaya seeds contain a variety of essential macro and micronutrients. The papaya seeds contain large amounts of

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... ents, including fibre which is effective for combating constipation and other digestive problems. Seeds can be used to treat health complications such as urinary tract infection, candidiasis and sepsis. Papaya seeds are sometimes used in salads and can even be used as a substitute for black pepper. Products developed from papaya seeds are considered to be nutritionally rich with diverse sources of all nutrients. Papaya seeds have the potential to produce oil with nutritional and functional properties highly similar to olive oil. The papaya seed, and products may be useful for bio-fuel, medicinal and industrial purposes. Therefore, Papaya seeds are usually thrown away but their proper utilization can lead to the development of novel drug in medicine and considered as safe for consumption. 'In this review subtopics covered are nutritional and Phytochemicals composition, antioxidant effect, antibacterial Activity, anthelminthic effect, Phytochemicals with Anticancer activity, Lycopene and isothiocyanate applications in papaya, papaya seed products and in vivo animal studies.'