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Evaluating the Potential of Applying Machine Learning Tools to Metabolic Pathway Optimization
2021
Biotechnology and Bioprocessing
Successful engineering of a microbial host for efficient production of a target product from a given substrate can be viewed as an extensive optimization task. Such a task involves the selection of high activity enzymes as well as their gene expression regulatory control elements (i.e., promoters and ribosome binding sites). Finally, there is also the need to tune expression of multiple genes along a heterologous pathway to relieve constraints from rate-limiting step and help reduce metabolic
doi:10.31579/2766-2314/060
fatcat:cdwgfaipjbdxln6mar7fvjndoy