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Lmx1b Is Required for Maintenance of Central Serotonergic Neurons and Mice Lacking Central Serotonergic System Exhibit Normal Locomotor Activity
Journal of Neuroscience
Central serotonergic neurons have been implicated in numerous animal behaviors and psychiatric disorders, but the molecular mechanisms underlying their development are not well understood. Here we generated Lmx1b (LIM homeobox transcription factor 1 ␤) conditional knock-out mice (Lmx1b f/f/p ) in which Lmx1b was only deleted in Pet1 (pheochromocytoma 12 ETS factor-1)-expressing 5-HT neurons. In Lmx1b f/f/p mice, the initial generation of central 5-HT neurons appeared normal. However, thedoi:10.1523/jneurosci.4143-06.2006 pmid:17151281 fatcat:fco6yiyozje2poiw4antrtbnkq