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PTMProphet: Fast and Accurate Mass Modification Localization for the Trans-Proteomic Pipeline
Spectral matching sequence database search engines commonly used on mass spectrometry-based proteomics experiments excel at identifying peptide sequence ions, and in addition, possible sequence ions carrying post-translational modifications (PTMs), but most do not provide confidence metrics for the exact localization of those PTMs when several possible sites are available. Localization is absolutely required for downstream molecular cell biology analysis of PTM function in vitro and in vivo.doi:10.1101/679845 fatcat:jd4ck3qnljdhhaugtp3jqgslx4