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and Purpose-Observations in patients with arterial aneurysms, fibromuscular dysplasia, and spontaneous cervical artery dissection (sCAD) indicate that protease inhibitor deficiency might boost the enzymatic destruction of arterial tissue and increase the risk of these arterial wall diseases. Here we present the first large investigation of the protease inhibitor hypothesis in patients with sCAD. Methods-Eighty patients with sCAD were compared with 80 age-and sex-matched healthy individuals. ␣ 1doi:10.1161/01.str.0000149631.52985.27 pmid:15550682 fatcat:3xf7i4kjlzac3ax6d6nqbtesb4