Effect of tranexamic acid in perioperative blood loss associated with total knee replacement: A KIMS experience
Journal of Medical and Scientific Research
Cost of allogenic blood transfusions and the associated risks mandate strategies to reduce blood loss in surgery. The objective of this study was to assess the efficacy of anti-fibrinolytic treatment in reducing perioperative blood loss during total knee replacement. Materials and methods: A retrospective and prospective study was carried out on 148 patients undergoing total knee replacement. 88 patients received tranexamic acid (10 mg/kg, iv) just before the cementation, 3 hours and 6 hours
... ours and 6 hours post operatively. 60 patients did not receive tranexamic acid. Perioperative blood loss was measured by the amount of post-operative drain, and drop in hemoglobin levels. The number of patients who needed blood transfusion and the number of units transfused was recorded and possible postoperative thromboembolic complications were studied clinically. Results: Amongst 88 patients (Group A) who were given tranexamic acid, only 35 (39.7%) were given blood transfusions and the average transfusion was 0.5 units. Amongst 60 patients (Group B) who were not given tranexamic acid, 45 (75%) were given blood transfusions and the average transfusions were 1.3 units. The average blood loss in the group of patients who were given tranexamic acid was 164.97ml while in the group which were not given, the average blood loss was 305.48ml. The average drop in Hemoglobin level in the group, which was given tranexamic acid was 1.5 grams%, and in the group, which was not given tranexamic acid was 1.8 grams%. Clinical assessment did not reveal any thromboembolic complications. Conclusions: Antifibrinolytic agents significantly decrease the blood loss in patients undergoing total knee replacement, which is clinically reflected by the reduction in the number of blood transfusions required. citation: Ashwinkumar AH, Bandari G, Reddy IV. Effect of tranexamic acid in perioperative blood loss associated with total knee replacement: Our experience.