Circadian blood pressure rhythm and intimal media thickness changes in non-dipper normotensives patients

Massimiliano Rocchietti March, Claudia Maggiore, Gerardo Salerno, Agostino De Venanzi, Elena Scaramucci, Patrizia Cardelli
2017 Italian Journal of Medicine  
<p>We investigated 25 non-dipper normotensive vs 25 dipper normotensive patients. The aim of our study was to evaluate carotid intimal-medial thickness (IMT) in the two groups. At the admission patients underwent anamnesis and general examination, blood sampling for lipid profile measurement, glycemia, homocysteine, ambulatory blood pressure measurement to assess the circadian blood pressure profile, and Doppler ultrasound to measure carotid intimal-medial thickness (IMT). Our results showed
more » ... r results showed that IMT is significantly higher in the non-dipper group (P&lt;0.006) vs dippers. Non-dipper status has been recognized in several studies a condition with increased risk for target organ damage in hypertensive and normotensive subjects. However, to our knowledge, a possible relationship between IMT and normotensive non-dipper patients has not yet clearly investigated. Our study instead has clearly demonstrated a significant relationship between IMT and the non-dipper status.</p>
doi:10.4081/itjm.2017.819 fatcat:zn3qsi2dvjbnbcaldxamst5qke