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Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappa
Journal of Virology
The Epstein-Barr virus (EBV) nuclear protein 3C (EBNA 3C) is essential for EBV-mediated transformation of primary B lymphocytes, is turned on by EBNA 2, and regulates transcription of some of the viral and cellular genes which are regulated by EBNA 2. EBNA 2 is targeted to response elements by binding to the DNA sequence-specific, transcriptional repressor protein J. We now show that EBNA 3C also binds to J. EBNA 3C causes J to not bind DNA or EBNA 2. J DNA binding activity in EBV-transformeddoi:10.1128/jvi.69.5.3108-3116.1995 fatcat:e57o36zbzbb3tlojkv2ot3xrnq