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Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations
1997
Antimicrobial Agents and Chemotherapy
Ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB], is a first-line drug used to treat tuberculosis. To gain insight into the molecular basis of EMB resistance, we characterized the 10-kb embCAB locus in 16 EMB-resistant and 3 EMB-susceptible genetically distinct Mycobacterium tuberculosis strains from diverse localities by automated DNA sequencing and single-stranded conformation polymorphism analysis. All 19 organisms had virtually identical sequences for the entire 10-kb region.
pmid:9257740
pmcid:PMC163984
fatcat:bsoazlta4bdejalgrtfctgupxa