A CLINICAL AND BACTERIOLOGICAL STUDY OF HEXAMETHYLENAMIN AS A URINARY ANTISEPTIC

LOUIS HENRY LEVY
1914 Archives of Internal Medicine  
The increasing use of hexamethylenamin for pathological conditions has led to more systematic studies of its chemical and bactericidal properties, and, as a result, recent literature abounds with papers on the subject. Following the discovery by Nicolaier,1 in 1894, that hexamethylenamin was broken down into formaldehyd in the urine, this drug was used extensively in infections of the genito-urinary tract. Up to 1902 the literature contained many papers on its use, a good review of which may be
more » ... iew of which may be found in the paper by Lubowski.2 For a few years after 1902 very little new work was done on hexamethylenamin as an antiseptic agent until 1908, when Crowe3 demonstrated its presence in body-fluids other than the urine. Since that time there has been a revival of interest in this drug and its uses, and as a result it has become more or less a panacea for many ills to which the body is heir. The findings of several of the recent workers not being entirely in harmony, and hexamethylenamin being used to a large extent in this hospital, it was deemed of interest to learn from personal experience in what conditions it is indicated. It was through the courtesy of the attending physicians of this hospital that permission was granted to use cases from their services and this opportunity is taken to thank them for their kindness and advice. Thanks are also due to the director of the laboratory for the use of laboratory records and material.
doi:10.1001/archinte.1914.00070170123008 fatcat:xoaxq6bnmfdhdlbjtl7z7x3phq