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A Critical E-box in Barhl1 3′ Enhancer Is Essential for Auditory Hair Cell Differentiation
2019
Cells
Barhl1, a mouse homologous gene of Drosophila BarH class homeobox genes, is highly expressed within the inner ear and crucial for the long-term maintenance of auditory hair cells that mediate hearing and balance, yet little is known about the molecular events underlying Barhl1 regulation and function in hair cells. In this study, through data mining and in vitro report assay, we firstly identified Barhl1 as a direct target gene of Atoh1 and one E-box (E3) in Barhl1 3' enhancer is crucial for
doi:10.3390/cells8050458
fatcat:br2iq3nwenhexldmwxh5gwfrue