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The Crossroads between RAS and RHO Signaling Pathways in Cellular Transformation, Motility and Contraction
Ras and Rho proteins are GTP-regulated molecular switches that control multiple signaling pathways in eukaryotic cells. Ras was among the first identified oncogenes, and it appears mutated in many forms of human cancer. It mainly promotes proliferation and survival through the MAPK pathway and the PI3K/AKT pathways, respectively. However, the myriad proteins close to the plasma membrane that activate or inhibit Ras make it a major regulator of many apparently unrelated pathways. On the otherdoi:10.3390/genes12060819 pmid:34071831 fatcat:m4wuwxomjnb4jel75dbhv3entq