Radiotherapy in palliative treatment of painful bone metastases

Andreja Horvat, Viljem Kovač, Primož Strojan
2009 Radiology and Oncology  
types of cancer with systemic dissemination, especially breast cancer, prostate and lung cancer, with the incidence of approximately 70%, 70% and 35%, respectively. 3 Lesions occurring in breast, lung, prostate and kidney comprise 80% of all metastases to bone. 4 Bone metastases are associated with considerable skeletal morbidity, including severe bone pain, spinal cord or nerve root compression, pathological fractures and hypercalcaemia. [5] [6] [7] [8] [9] Although the skeleton receives only
more » ... eton receives only 10% of the cardiac output, metastases in the skeleton are very common as compared to metastases to other tissues receiving a far greater amount of the cardiac output. 10 The bone metastases are found almost invaria- Background. Pain caused by bone metastases is the most common symptom requiring the treatment in cancer patients. Bone metastases often present as the first evidence of disseminated disease, the most common primary sites being breast, prostate, and lung. Important in palliative treatment is to reach a maximal effect with the minimal treatment. The aim of palliation for cancer patients is to increase the quality of their remaining life. Conclusions. The management of bone pain includes analgesics, local treatment (radiation, surgery) and systemic treatment (hormones, chemotherapy, radioisotopes and agents such as bisphosphonates). The treatment of bone cancer pain often requires a multidisciplinary approach. Radiotherapy remains the most important palliative treatment for localized bone pain. The treatment duration can generally be reduced to a single treatment with excellent and long-lasting palliative analgesic responses. The treatment should be individualized according to the patient's clinical condition and life expectancy.
doi:10.2478/v10019-009-0038-4 fatcat:mhgxphztzfgadag45t3eyseeeq