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Primary sensory neurons of the dorsal root ganglia (DRG) regenerate their spinal cord axon if the peripheral nerve axon has previously been cut. This conditioning lesion confers axon growth competence to the neurons. However, the signal that is sensed by the cell upon peripheral lesion to initiate the regenerative response remains elusive. Results: We show here that loss of electrical activity following peripheral deafferentiation is an important signal to trigger axon regrowth. We firstdoi:10.1016/j.cub.2010.05.055 pmid:20579880 fatcat:gqv72sgxtnfvrpbisiru4kzeb4