The 64 patients with severe acute pancreatitis at admission in hospital arterial hypertension, low venous saturation of oxygen (ScvO2), hyperlactemia, oligoanuria and hypercreatininemia were observed. This occurrence became an indication for infusion therapy to recover and optimize hemodynamics. After 6 hours of therapy, 30 patients were lacked increasing of diuresis related to infusion load and hypercreatininemia increased and also significantly increased positive fluid balance s compared to

more »

... her patients. These 30 patients were additionally applied hemofiltration during 66 hours. The infusion therapy was characterized by difficulty of restoration and optimization of hemodynamic, large volumes of infusion mediums та frequent application of sympathomimetics. In patients without hemofiltration a significant increasing of cumulative fluid balance was added. The hemofiltration permitted to normalize diuresis, to prevent surplus cumulation of fluid and to support blood circulation at the optimal level.