Ultra-small superparamagnetic particles of iron oxide in magnetic resonance imaging of cardiovascular disease

Colin Stirrat, Alex Vesey, Olivia McBride, Jennifer Robson, Shirjel Alam, William Wallace, Scott Semple, Peter Henriksen, David Newby
2014 Journal of Vascular Diagnostics  
Journal of Vascular Diagnostics Dovepress submit your manuscript | www.dovepress.com Dovepress 99 R e V i e w open access to scientific and medical research Open Access Full Text Article Abstract: Ultra-small superparamagnetic particles of iron oxide (USPIO) are iron-oxide based contrast agents that enhance and complement in vivo magnetic resonance imaging (MRI) by shortening T1, T2, and T2* relaxation times. USPIO can be employed to provide immediate blood pool contrast, or to act as
more » ... markers of cellular inflammation through uptake by inflammatory cells. They can also be targeted to specific cell-surface markers using antibody or ligand labeling. This review will discuss the application of USPIO contrast in MRI studies of cardiovascular disease.
doi:10.2147/jvd.s50036 fatcat:65qy2xtzyvbmxbnyg65avaqr34