Long time behaviour of diffusing particles in constrained geometries; application to chromatin motion

A Rosa, F R Neumann, S M Gasser, A Stasiak
2006 Journal of Physics: Condensed Matter  
Inspired by experiments that use single-particle tracking to measure the regions of confinement of selected chromosomal regions within cell nuclei, we have developed an analytical approach that takes into account various possible positions and shapes of the confinement regions. We show, in particular, that confinement of a particle into a subregion that is entirely enclosed within a spherical volume can lead to a higher limit of the mean radial square displacement value than the one associated
more » ... ith a particle that can explore the entire spherical volume. Finally, we apply the theory to analyse the motion of extrachromosomal chromatin rings within nuclei of living yeast.
doi:10.1088/0953-8984/18/14/s08 fatcat:eln6bvdn55h3dfsekpxbo4x4yi